Research To Prevent Renal Transplant Rejection
First Published: Investigator - April 2005
Advanced renal failure carries a very high risk of death from heart attack and stroke.
Amongst other abnormalities in blood chemicals and hormones, patients with renal failure often have a hardening of their arterial vessels which, in turn, increase the blood pressure causing further damage to the kidneys.
The Flinders Medical Centre Foundation has provided funding to Flinders Department of Clinical Pharmacology for a pilot study aimed to investigate the effects of renal transplantation on the stiffening of the arterial vessels.
Renal transplant patients will be studied before and after the transplant operation to see if they show minimal change or significant improvement in their vascular outcome.
Through this study Drs Arduino Mangoni and Jeff Barbara hope to be able to identify vascular changes if any, just after transplant and therefore be in a better position to identify those at risk.
‘Unfortunately some renal transplant patients have some degree of early vascular disease with a high risk of rejection later on. If we can pick them up at an early stage, rejection may be prevented’, said Dr Mangoni.
“We will measure the stiffness of the vessels before and shortly after the operation with a simple, safe and non invasive test. This will assist us to better identify and characterize those patients showing minimal change or improvement in stiffness post-transplant. Some people do well, some people not so well. We want to see if different degrees of improvement of the transplant could be predicted for late rejection”
Dr Mangoni’s project will hopefully lead to a larger project to test the hypothesis that arterial stiffness is an independent predictor of renal transplant rejection.